Anticoagulants, Antiplatelets, and Thrombolytics (Methods in by Shaker A. Mousa

By Shaker A. Mousa

1This number of evaluation articles highlights the most recent improvement of antithrombotics and gives confirmed experimental equipment for the additional improvement of latest and better anticoagulants. one of the state-of-the-art advancements reviewed are the unconventional utilization of low molecular weight heparins, such antithrombin brokers because the hirudin, and such antiplatelet medicines because the GPIIb/IIIa inhibitors and ADP receptor antagonists. extra options mentioned contain aspirin and clopidogrel, the increased use of polytherapeutic methods, antiproteases (factors IIa, Xa, and VIIa), tissue issue concentrating on, platelet receptor focusing on, and antithrombin III modulation.

Show description

Read or Download Anticoagulants, Antiplatelets, and Thrombolytics (Methods in Molecular Biology) PDF

Best hematology books

Anemia in the Elderly

Anemia within the aged has been safely outlined because the silent epidemic, representing three million humans within the usa elderly sixty five years and older. occurrence and occurrence of this raise with age. It differs in its etiology, pathogenesis and remedy from anemia in young ones and more youthful adults.

Chronic Lymphocytic Leukemia

Written via authors from the world’s so much favorite melanoma facilities, continual Lymphocytic Leukemia offers a complete, updated photograph of CLL and the way to higher deal with sufferers inflicted with the disorder. New info on advancements within the molecular pathogenesis of this ailment affects how physicians process and deal with sufferers with CLL.

Phenotypic and Genotypic Diagnosis of Malignancies: An Immunohistochemical and Molecular Approach

Rigorously designed as a simple and fast reference, this laptop handbook is for operating pathologists who have to make certain the actual form of melanoma they're facing in a sufferer. To this finish, the ebook includes many huge tables of data to permit a quick research of effects, offering the entire proper info to diagnose the entire variety of other tumors in people.

Management of Hemostasis and Coagulopathies for Surgical and Critically Ill Patients: An Evidence-Based Approach

Administration of Hemostasis and Coagulopathies for Surgical and seriously sick sufferers: An Evidence-Based method deals a concise consultant to a sub-specialty of transfusion drugs from the scientific laboratory standpoint. It specializes in the scientific assessments which may be performed in the course of preoperative overview, intraoperative, and postoperative evaluation and administration of surgical or seriously sick sufferers.

Additional resources for Anticoagulants, Antiplatelets, and Thrombolytics (Methods in Molecular Biology)

Sample text

Clin. Cardiol. ), L112–L114. 33. Alonso, A, for the AMI-SK Investigators. Preliminary results of the AMI-SK trial. Am. Coll. Cardiol. 50th Scientific Session, March 2001, Orlando, Florida. 34. Baird, S. , Menown, I. B. , McBride, S. , Trouton, T. , and Wilson, C. (2002) Randomized comparison of enoxaparin with unfractionated heparin following fibrinolytic therapy for acute myocardial infarction. Eur. Heart J. 23, 627–632. 35. Direct Thrombin Inhibitor Collaboration Investigators (2002) Direct thrombin inhibitors in acute coronary syndromes: principal results of a meta-analysis based on individual patient’s data.

The half-life CH04,35-48,14pgs 9/5/03 11:01 AM Page 39 Heparin and LMWH in Thrombosis 39 Table 1 UFH vs LMWH UFH Continuous, iv infusion Primarily administered in hospital Usually administered by healthcare professionals Monitoring and dosing adjustments Frequent dosing errors Risk of thrombocytopenia and osteoporosis Cheap, but not cost-effective Requires 5–7 d in the hospital LMWH BID or QD sc injection Administered in hospital, office, or home Administered by patient, caregiver, or professional No monitoring, fixed, or weight-based dosing More precise dosing Decreased risk of adverse events Demonstrated pharmacoeconomic benefits Requires 0–2 d in the hospital of LMWHs enoxaparin, deltaparin, tinzaparin, and others has been documented to be between ~100 and 360 min, depending on whether the administration of LMWH was iv or sc.

A. , Totowa, NJ 21 CH03,21-34,14pgs 22 9/5/03 11:01 AM Page 22 McCarty et al. and the presence of both GPIb/IX and GPIIb/IIIa on the platelet membrane. It has been postulated that at high shear stress conditions, the interaction of vWF with the GPIb/IX complex is the initial event that triggers platelet activation, as well as the binding of vWF to GPIIb/IIIa to induce platelet aggregate formation (4). Several studies have identified the pivotal role of GPIIb/IIIa in arterial thrombosis. Thus, this platelet integrin receptor has emerged as a rational therapeutic target in the management of acute coronary syndromes (ACS).

Download PDF sample

Rated 4.13 of 5 – based on 41 votes