ADAMTS13: Biology and Disease by George M. Rodgers

By George M. Rodgers

This accomplished quantity discusses the protease ADAMTS13, summarizing the present prestige of simple and scientific examine. The 9 authoritative chapters start with a ancient standpoint via exploration of the biochemistry and structure-function relationships of ADAMTS13 in addition to its basic functionality in hemostasis (cleavage of von Willebrand factor). rising study topics for ADAMTS13 are coated, together with its power position in angiogenesis and different elements of cellphone biology. extra subject matters contain laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and bought ADAMTS13 deficiency. A bankruptcy on comparable thrombotic microangiopathic (TMA) problems examines the variations among TMAs linked to ADAMTS13 deficiency and people now not linked to ADAMTS13 deficiency. a last bankruptcy stories the initial info on rising features of ADAMTS13, corresponding to the prestige of recombinant ADAMTS13 items and their strength utility.


Comprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and affliction is an important source for scientific hematologists, transfusion drugs physicians, and researchers drawn to hemostasis, vascular biology, biochemistry, and metalloproteases.

Show description

Read Online or Download ADAMTS13: Biology and Disease PDF

Similar hematology books

Anemia in the Elderly

Anemia within the aged has been thoroughly outlined because the silent epidemic, representing three million humans within the usa elderly sixty five years and older. occurrence and incidence of this situation bring up with age. It differs in its etiology, pathogenesis and remedy from anemia in little ones and more youthful adults.

Chronic Lymphocytic Leukemia

Written via authors from the world’s such a lot well-liked melanoma facilities, persistent Lymphocytic Leukemia offers a finished, up to date photo of CLL and the way to raised deal with sufferers inflicted with the sickness. New details on advancements within the molecular pathogenesis of this ailment affects how physicians procedure and deal with sufferers with CLL.

Phenotypic and Genotypic Diagnosis of Malignancies: An Immunohistochemical and Molecular Approach

Rigorously designed as a simple and fast reference, this computing device guide is for operating pathologists who have to be sure the actual kind of melanoma they're facing in a sufferer. To this finish, the ebook includes many huge tables of knowledge to permit a quick research of effects, supplying all of the appropriate details to diagnose the complete variety of other tumors in people.

Management of Hemostasis and Coagulopathies for Surgical and Critically Ill Patients: An Evidence-Based Approach

Administration of Hemostasis and Coagulopathies for Surgical and significantly in poor health sufferers: An Evidence-Based procedure deals a concise advisor to a sub-specialty of transfusion medication from the medical laboratory standpoint. It specializes in the scientific assessments that could be performed in the course of preoperative review, intraoperative, and postoperative overview and administration of surgical or seriously unwell sufferers.

Extra resources for ADAMTS13: Biology and Disease

Sample text

2005;16:1177–83. Noris M, Remuzzi G. Atypical hemolytic-uremic syndrome. N Engl J Med. 2009;361: 1676–87. Tsai HM, Chandler WL, Sarode R, Hoffman R, Jelacic S, Habeeb RL, Watkins SL, Wong CS, Williams GD, Tarr PI. Von Willebrand factor and von Willebrand factor-cleaving metalloprotease activity in Escherichia coli O157:H7-associated hemolytic uremic syndrome. Pediatr Res. 2001;49:653–9. Hosler GA, Cusumano AM, Hutchins GM. Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome are distinct pathologic entities.

Cleavage of the ADAMTS13 propeptide is not required for protease activity. J Biol Chem. 2003;278(47):46643–8. 25. Kubota Y, Sano M, Goda S, Suzuki N, Nishiwaki K. The conserved oligomeric Golgi complex acts in organ morphogenesis via glycosylation of an ADAM protease in C. elegans. Development. 2006;133(2):263–73. 26. Nishiwaki K, Kubota Y, Chigira Y, Roy SK, Suzuki M, Schvarzstein M, Jigami Y, Hisamoto N, Matsumoto K. An NDPase links ADAM protease glycosylation with organ morphogenesis in C. elegans.

J Biol Chem. 2006;281(18):12485–94. 38. Longpre JM, Leduc R. Identification of prodomain determinants involved in ADAMTS-1 biosynthesis. J Biol Chem. 2004;279(32):33237–45. 39. Longpre JM, McCulloch DR, Koo BH, Alexander JP, Apte SS, Leduc R. Characterization of proADAMTS5 processing by proprotein convertases. Int J Biochem Cell Biol. 2009; 41(5):1116–26. pii: S1357-2725(08)00414-7. 008. Epub 2008/11/11. 40. Tortorella MD, Arner EC, Hills R, Gormley J, Fok K, Pegg L, Munie G, Malfait AM. ADAMTS-4 (aggrecanase-1): N-terminal activation mechanisms.

Download PDF sample

Rated 4.14 of 5 – based on 41 votes